Please enable it to take advantage of the complete set of features! Until now, great emphasis has been placed on the harmful effects of solar radiation on the skin. The impact score (IS) 2021 of Vascular Pharmacology is 5.26, which is computed in 2022 as per its definition.Vascular Pharmacology IS is decreased by a factor of 0.05 and approximate percentage change is -0.94% when compared to preceding year 2020, which shows a falling trend. Table 5 IS may decrease in 2023 as well. Table 2 Effects of ozone in normal human epidermal keratinocytes. Flow chart for determining crude reporting odds ratios (cRORs) and adjusted RORs (aRORs) of methotrexate (MTX)-related adverse events. FLG is vital for keratinocytes to acquire the properties of physical force through the aggregation of the keratin packages of the upper epidermal strata. ). Pollutants induce the production of NALP3a. et al., 2019). The Convention of Stockholm in 2001 identified 12 POPs or the dirty dozen. According to the source, POPs can be grouped into three categories: i) pesticides that, although banned, are still used in some countries, ii) POPs whose origins are from the industry, like polychlorinated biphenyls (PCB), and iii) unintended industrial by-products. Disclaimer. The United States Environmental Protection Administration (EPA) has included seven PAH in group B2 (probable human carcinogens): benzo anthracene, chrysene, benzo(a)pyrene, benzo(b)fluoranthene, benzo(k)fluoranthene, dibenzo(a,h)anthracene, and indene(1,2,3-cd)pyrene (Working Group on Polycyclic Aromatic Hydrocarbons, 2001).
Frontiers in Pharmacology | Journal Report See this image and copyright information in PMC. FOIA Prevention or management of adverse reactions, including interstitial lung disease (ILD), hepatotoxicity, myelosuppression, and infection, remains fundamental for safe MTX therapy. How Uv light touches the brain and endocrine system through skin, and why. et al., 2019). The overall rank of Frontiers in Pharmacology is 3797 . Bookshelf TCDD increased the population of macrophages within the tissue in the later stages of healing (Moirangthem et al., 2013). Pharmacol.. Also, IcdP and UVA1 affected mitochondria by triggering superoxide production and membrane depolarization. DSC1 is associated with differentiation and keratinization. Manuscript and review quality at this stage are enhanced by allowing authors and reviewers to discuss directly with each other in real-time until they reach consensus and a final version of the manuscript is endorsed by the reviewers. The distance of residence to the nearest road was also associated with more pigment spots, but this effect did not reach significance (Vierktter et al., 2010). Exposure of the skin to PM induces lipid peroxidation, ROS, DNA damage, apoptosis, and extracellular matrix damage (Magnani et al., 2016; Lee et al., 2016a; Zhang et al., 2017a; Idowu et al., 2019). ). In the troposphere, it is considered to be a secondary contaminant because it is formed through primary chemical precursor reactions. 2023 May 23;23(1):520. doi: 10.1186/s12913-023-09523-3. 18, 427436. NHEK exposed to daily UVA1 (350400 nm) combined with PAH has shown significant synergistic phototoxicity damage. Oxidative stress, inflammation, and damage of the cutaneous barrier and in the extracellular matrix are effects of pollution and are observed in skin aging. Unauthorized use of these marks is strictly prohibited. (2013). As shown in in vitro and in vivo studies, environmental contaminants such as PAH and TCDD and dioxins produce hyperpigmentation by increasing the enzymes that synthesize melanin via AhR activation (Luecke et al., 2010). Also, the skin is colonized by an abundant and diverse community of microbes, known as microbiome (Dbrowska et al., 2018). None have a financial incentive to accept articles, i.e. Similarly, UVA activated NOX activity decreasing FLG expression (Valencia and Kochevar, 2008). Table 1 article types: and transmitted securely. Application of melatonin-loaded poly(N-isopropylacrylamide) hydrogel particles to reduce the toxicity of airborne pollutes to RAW264.7 cells. The binding of PM2.5 to TLR5 initiated the intracellular signaling that led the translation of NFB into the nucleus and the increment of IL-6 (Ryu et al., 2019) ( Finally, also the cytosol produces ROS as a product of the metabolism of arachidonic acid. Availableat. and transmitted securely. The role of TRPV1 channel in aged human skin. skin aging, air pollutant, oxidative stress, inflammation, photo-pollution. See our editorial guidelines for everything you need to know about Frontiers peer review process. Front. Very recently, Krutmann group (Fuks et al., 2019) addressed the effects of O3 in the skin in two densely urbanized areas of Germany: the area of the SALIA cohort in Ruhr area, and the BASE-II cohort in Berlin. (2015). These effects could be amplified by the damaging synergy of the sun, especially UVA rays and pollution. The immunological barrier and antimicrobial defense are aspects of great importance in the cutaneous barrier. Before In a word, our findings suggest that DL-NBP may be a potential therapeutic . ). Exposure to ultraviolet radiation (UVR) is related to the appearance of skin cancer. 8600 Rockville Pike Table 2 However, some environmental factors could make the skin vulnerable. These signs on aged skin are related to impaired enzymatic processes, partly due to the decrease in the water content of SC (Toni et al., 2017). ISSN (Print): 1570-1611. The publisher of Frontiers in Pharmacology is Frontiers Media S.A.. Haarmann-Stemmann T., Esser C., Krutmann J. 2023. Leijs M. M., Esser A., Amann P. M., Schettgen T., Heise R., Fietkau K., et al. Therefore, aging caused by the environment is currently a fundamental element to take into account in health. In epidermal KC, AhR activation results from the absorbance of UVB radiation by tryptophan (Trp). . This journal supports open access. Its coverage history is as follows: 2010-2022. Slominski A., Zmijewski M. A., Pawelek J. Table 3 Photodamage contributes to the formation of lentigo senile in human skin defined as the result of chronic exposure to a variety of environmental factors including UVR (Krutmann et al., 2014). However, a model of senescence in keratinocytes and fibroblast induced by PM has been described (Qiao et al., 2017). Disclaimer. Ultimately, all the processes previously related produce direct and indirect toxicity to the skin (Mancebo and Wang, 2015; Krutmann et al., 2017). Environmental stress, in the skin, as occurs in photoaging, can produce activation of the hypothalamicpituitaryadrenal (HPA) axis either by nervous route or by humoral factors. Within the PAH, B[a]P has been the most studied due to its carcinogenicity in humans (Stockholm Convention, 2011). Biologics or tofacitinib for rheumatoid arthritis in incomplete responders to methotrexate or other traditional disease-modifying anti-rheumatic drugs: a systematic review and network meta-analysis. Therefore, long-term exposure to tropospheric O3 can contribute to skin aging ( Mitochondrial deterioration induced by contamination and UVR should be considered as a relevant mechanism involved in synergistic skin effects (Soeur et al., 2017) ( 9, 649657.
Proton Pump Inhibitor and Tacrolimus Uses are Associated With The treatment of cells with a p38 MAPK (AP-1) or NF- inhibitors reduced the increased levels of TRPV 1 induced by PM. ). These changes may also lead to increased production of free radicals (Tulah and Birch-Machin, 2013). Patrizi B., Siciliani de Cumis M. (2018). Slominski A. T., Zmijewski M. A., Zbytek B., Tobin D. J., Theoharides T. C., Rivier J. Those dimer creations are the basis of mutations in specific genes, including the tumor suppressor gene p53. the following (2017). The WHO considers six types of air pollutants: particulate matter, nitrogen dioxide, sulfur dioxide, black carbon, carbon monoxide, and ground-level ozone (World Health Organization, 2012). In general, individuals wear a skin that reflects several stages of extrinsic aging, superimposed on the level of intrinsic aging. (2003). Enter journal title, issn or abbr in this box to search. (2015. b). Funder mandates such as those by the Wellcome Trust (UK), National Institutes of Health (USA) and the Australian Research Council (Australia) are fully compatible with publishing in Frontiers. Retinoic acid co-treatment aggravates severity of dioxin-induced skin lesions in hairless mice via induction of inflammatory response. Table 3 However, ROS are also produced in the endoplasmic reticulum (ER) being members of the cytochrome P450 family, the main ROS producers. Photo-pollution stress in skin: traces of pollutants (PAH and particulate matter) impair redox homeostasis in keratinocytes exposed to UVA1. 2017 May 8;5(5):CD012657. Skobowiat C., Broyna A. -. The International Journal of Pharmaceutics is the second most cited journal in the "Pharmacy & Pharmacology" category out of 358 journals, being the true home for pharmaceutical scientists concerned with the physical, chemical and biological properties of devices and delivery systems for drugs, vaccines and biologicals, including their design . BMC Health Serv. (2019) proposed that skin barrier disruption is due to the apoptotic action PM and the decrease in the keratinocyte proliferation. Combining MTX with folic acid (FA) or tumor necrosis factor-alpha inhibitors (TNFis) tended to reduce cRORs for these adverse events (except for TB). Cysteine-rich protein 61 (CCN1) mediates replicative senescence-associated aberrant collagen homeostasis in human skin fibroblasts. Check out Congress Announcements Table 1 Eckers A., Jakob S., Heiss C., Haarmann-Stemmann T., Goy C., Brinkmann V., et al. Perillaldehyde inhibits ahr signaling and activates nrf2 antioxidant pathway in human keratinocytes. Start your submission and get more impact for your research by publishing with us. The formation of lipid hydroperoxides was inhibited by superoxide dismutase. Besides, PM2.5 induced in vitro a direct interaction between TLR5 and NOX4 (Ryu et al., 2019). Drug shortages in Israel: regulatory perspectives, challenges and solutions. National Library of Medicine causes; definitions; drug shortage; impacts; medicine shortage; mitigation strategies. (2012. a). Also, DNA can be damaged by the ROS generated during the metabolic activation of PAH (Tsuji et al., 2011) thus owing high toxicity, mutagenic, and/or carcinogenic effects (Idowu et al., 2019). On the other hand, extrinsic factors can alter skin immunity and the immune system of skin interacts with the neuroendocrine responses (Slominski et al., 2012b; Slominski et al., 2018a). Frontiers in Pharmacology Published by Frontiers Online ISSN: 1663-9812 Recent articles A flavonoid-rich fraction of Euphorbia peplus attenuates hyperglycemia, insulin resistance and oxidative. (2 years)). (2018). The average 5-year exposure to UVR has been estimated using NASA satellite data and data from the German Climate Center. PM2.5 can pass the pulmonary barrier and reach the blood. This journal's impact score, h-index, and SJR are 5.35, 129, and 1.064, respectively.
Journal impact: Frontiers in Pharmacology It is computed in the year 2023. Assessing human exposure to organic pollutants in the indoor environment. Meanwhile, electron spin resonance indicated that singlet oxygen and a superoxide radical anion were generated from UVA photoirradiation of B[a]P products in a light-dose responding manner (Xia et al., 2015) ( the combined impact of these two factors seems to contribute to increased tumorigenicity in animals (Wang et al., .
ISSN: 1664-1078 . Reviewers can recommend rejection at this stage if their requests to correct objective errors are not being met by the authors or if they deem the article overall of insufficient quality. Frontiers is well aware of the potential impact of published research both on future research and on society and, hence, does not support superficial review, light review or no-review publishing models. In intrinsic aging, reactive oxygen species (ROS) are produced through cellular oxidative metabolism. Frontiers in Pharmacology generally endorses the relevant principles described in the4 pillars of ethnopharmacologyfor all studies involving natural products submitted to all specialty sections in the journal.
Journal of Cardiovascular Pharmacology - Impact Factor, Overall Ranking European Journal of Pharmacology - Impact Factor, Overall Ranking TCDD is responsible for a variety of toxic effects via AhR signaling pathways (Patrizi and Siciliani de Cumis, 2018). The janus-faced role of aryl hydrocarbon receptor signaling in the skin: consequences for prevention and treatment of skin disorders, Particulate matter air pollution: effects on the cardiovascular system. -, Fragoulis G. E., Nikiphorou E., Larsen J., Korsten P., Conway R. (2019). Finally, we reflect on how components of environmental stress can interact with ultraviolet radiation to cause cell damage and the critical importance of knowing the mechanisms to develop new therapies to maintain the skin without damage in old age and to repair its diseases. TCDD toxicity mediated by epigenetic mechanisms, Carcinogenic potency of airborne polycyclic aromatic hydrocarbons in relation to the particle fraction size. In a recent review, Burke reported that B[a]P, even at low levels when combined with UVA, contributes to increased oxidative damage in the skin, with an increase in extrinsic aging and tumorigenicity (Burke and Wei, 2009). When submitting a manuscript to Frontiers in Pharmacology, authors must When PAH is metabolized through the enzymes of phase I, it can be covalently bound to the DNA that forms the PAH-DNA adducts (Froehner et al., 2018). Arachidonic acid levels are relatively low in the skin but they increase in skin aging (Rinnerthaler et al., 2015). PM represents an important factor that contributes to extrinsic skin aging in humans (Vierktter et al., 2010; Li et al., 2015; Hls et al., 2016; Krutmann et al., 2017; Burke, 2018). (2013. a). Accessibility Reviewing a manuscript? KRT 16 and 17 are markers of epidermal proliferation and responsible for the mechanical integrity of the keratinocytes. Table 1 Please check the official website of this journal to find out the complete details and Call For Papers (CFPs). Chaiprasongsuk A., Janjetovic Z., Kim T. K., Jarrett S. G., DOrazio J. Toni R. J., Kezi S., Hadavdi S. L., Marinovi B. Skin damage mechanisms related to airborne particulate matter exposure, Recognizing the impact of ambient air pollution on skin, Pollution and sun exposure: a deleterious synergy, Signaling by ROS drives inflammasome activation. Back Journal Home. Thus, chronic exposure to O3 produces oxidative damage in the stratum corneum, which generates free-radical species. AAPS PharmSciTech. Careers. (2010). It induces the translocation of AhR to the nucleus and upstream to the promoter of the CYP1A1 gene as well as other Ah-responsive genes that regulate the expression of proinflammatory genes and genes related to the dioxin metabolism. Therefore, activation of AhR is critical in the increase of proinflammatory responses (ODriscoll and Mezrich, 2018). This site needs JavaScript to work properly. The Hoseinzadeh studies have shown that tropospheric O3 and PM are independent risks for decreasing the levels of VD and cause deficiency of this vitamin. Exposure of human skin to benzo[a]pyrene: role of CYP1A1 and aryl hydrocarbon receptor in oxidative stress generation. On the role of skin in the regulation of local and systemic steroidogenic activities. 2022 Mar 30;19(7):4102. doi: 10.3390/ijerph19074102. Fernblock prevents dermal cell damage induced by visible and infrared a radiation. sharing sensitive information, make sure youre on a federal Valacchi in 2017 (Valachhi et al., 2017) exposed the forearm skin of 15 volunteers to 0.8 ppm and showed a significant increase of 4-HNE and 8-iso-prostaglandin-F(2) (IsoP) compared to non-exposed skin. ISO 4 is an international standard which defines a uniform and consistent system for the abbreviation of serial publication titles, which are published regularly. In vivo ozone exposure induces antioxidant/stress-related responses in murine lung and skin. In addition, studies performed in NHEK have confirmed that photo-pollution is more dangerous than by pollution alone (Soeur et al., 2017). The latest impact score (IS) of the Frontiers in Pharmacology is 5.35. Front Pharmacol. In humans, chloracne is the most surprising toxic phenomenon due to exposure to TCDD. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide. (2018). The rank of this journal is 3797. 2021 (2022 update) 5.195. It also alters the levels of TGB- (Slominski et al., 2018a). The production of ROS in the mitochondria of keratinocytes occurs in the deepest cells of the epidermis, especially in the stem cells at the basal layer; in the final process of differentiation, the keratinocytes stratum corneum lose their organelles. Melatonin also prevents free radicals from damaging proteins so it can be considered as an agent that prevents intrinsic skin aging and photo aging. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).
Frontiers in Pharmacology - SCI Journal Some AhR ligands modulate the regulatory T cells differentiation or increase the proinflammatory differentiation of Th 17. (2020). FLG contributes to epidermal hydration (Lee et al., 2012). Albrecht S., Jung S., Mller R., Lademann J., Zuberbier T., Zastrow L., et al. On the other hand, PM also causes alterations to the skin barrier. Pharm. Lee C. W., Lin Z. C., Hsu L. F., Fang J. Y., Chiang Y. C., Tsai M. H., et al. TLR2 and TLR4 mediated host immune response in major infectious disease: a review. New regulatory strategies to manage medicines shortages in Europe. Would you like email updates of new search results? The aryl hydrocarbon receptor promotes aging phenotypes across species. In the mitochondria, O3 decreases ATP and sirtuin 3, a protein related to the elimination of free radicals. This is the number assigned to your article by the publisher, and it is the one you will use to reference your article within the library catalogues. 18, 739. , (2018). However, it is still necessary to obtain exhaustive conclusions about the impact of air pollution on VD deficiency. Bethesda, MD 20894, Web Policies
Frontiers in Pharmacology - Scimago Journal & Country Rank Although studies assessing spontaneous reporting systems have limitations such as reporting bias, data from our logistic regression analysis demonstrated that adding FA to MTX-based therapy could help reduce the dose-dependent adverse events of MTX, thereby providing clinical evidence that supports the beneficial effect of FA. Ozone exposure activates oxidative stress responses in murine skin, Nox1-based NADPH oxidase is the major source of UVA-induced reactive oxygen species in human keratinocytes. Environmental effects of ozone depletion, UV radiation and interactions with climate change: UNEP Environmental Effects Assessment Panel, update 2017, Vitamin D receptor, UVR, and skin cancer: a potential protective mechanism, Protective actions of vitamin D in UVB induced skin cancer, Mechanisms of aging and development-A new understanding of environmental damage to the skin and prevention with topical antioxidants, Synergistic damage by UVA radiation and pollutants, Vitamin D: dietary requirements and food fortification as a means of helping achieve adequate vitamin D status. Quantitative signal detection using spontaneous ADR reporting. HHS Vulnerability Disclosure, Help 8600 Rockville Pike In its inactive state in the cytosol, AhR forms a protein complex. Melatonin under conditions of oxidative stress acts as a local antioxidant, decreasing mitochondrial damage. (2015). By TEM, PM2.5 has been found inside HaCat cells in the mitochondria, cytoplasm, and nucleus also providing a molecular insight into PM2.5-induced skin injury (Zhang et al., 2017b) ( Research is the product of an investment by society and therefore its fruits should be returned to all people without borders or discrimination, serving society universally and in a transparent fashion. Federal government websites often end in .gov or .mil. Therefore, Frontiers only applies the most rigorous and unbiased reviews, established in the high standards of the Frontiers Review System. Synergistic effects of UVA and UVB radiation and benzo(a)pyrene (B[a]P) and particulate matter (PM) in the skin. Aging is due to extrinsic and intrinsic factors. 10.1586/1744666X.2013.811173 In this review, we describe, based on in vitro studies, in animals and in humans, the mechanisms that cause damage due to air pollutants in the skin and how they influence skin aging.
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