KIIT Univ, Sch Biotechnol, Bhubaneswar 751024, India. Differential expression of histone deacetylase and acetyltransferase genes in gastric cancer and their modulation by trichostatin A. Li Y, et al. The influence of upregulation and downregulation of molecular effector post-treatment with miRNA and siRNA and their impact on the clinical setting has been elucidated. Choudhury, A., Simnani, F. Z., Singh, D., Patel, P., Sinha, A., Nandi, A., . more, You seem to have JavaScript disabled. This in turn greatly influences the biological activity of fucoidans, with high degree of sulphation and low molecular weight particularly linked with increased biological activity. Pritam Kumar Panda. The sushi is really fresh, They make everything with the good amount of ingredient and the sushi is really tight that you can taste all with one bite. The three outputs (in white nodes) of the network are proliferation, cell cycle arrest, and apoptosis, respectively. We conducted two separate perturbations of each node. Pritam Kumar All gists 4 Sort: Recently created 1 file 0 forks 0 comments 0 stars developer-pritam / gpt.js Last active 2 months ago GPT Plugin for levender WhatsApp MD script View gpt.js const axios = require ('axios') const config = require ('../config') The green chemistry route has become extremely popular due to its use in the synthesis of nanoparticles. Boolean models of regulatory networks were meant to simplify the dynamics of complex biological systems16. Zhou Y, Chen B. GAS5-mediated regulation of cell signaling (Review). Pritam Kumar Panda. The first three fixed points belong to the wild-type case. Careers, Unable to load your collection due to an error. The other two following fixed points indicate the knockdown (KO) of ATM. Predicting effective microRNA target sites in mammalian mRNAs. The sushi even there was good ideas unfortunately taste mediocre sushi The starters were really good which was nice surprise. Interestingly, all these results are in excellent agreement with in-vivo/in-vitro experiments3,15 in GC. S.G. designed and conceptualized the study, S.G, P.K.P, and R.F.H analyzed the results, S.G. and P.K.P. The network predictions correspond with the gain-and-loss of function investigations in the additional two cell lines (HeLa and MCF-7). Shantanu Gupta, # 1 Pritam Kumar Panda, # 2 Wei Luo, 2 Ronaldo F. Hashimoto, # 1 and Rajeev Ahuja 2, 3 Shantanu Gupta 1 Departamento de Cincia da Computao, Instituto de Matemtica e Estatstica, Universidade de So Paulo, Rua do Mato 1010, So Paulo, SP 05508-090 Brasil This work highlights the critical factors hidden in the protein networks, linking with their experimental photocycle kinetics. DNA damage and oxidant stress activate p53 through differential upstream signaling pathways. As you can see, only the ATM/p38 MAPK pathway is activated and triggers cell cycle arrest and apoptosis in response to DNA damage. . The molecular process of neuropsychiatric disorders is closely connected to modifying the genetic structures inherited or caused by damage, toxic chemicals, and some current diseases. Gu Y, et al. We found that cell fate decisions such as cell cycle arrest and/or apoptosis are independent of p53 status in GC cells as suggested by these in-vivo/in-vitro studies7,8,49. panda is the nicest universal car interface ever. As you can see, loss-of-function (LoF) of p38 MAPK in response to DNA damage, lncRNA-GAS5 expression is accelerated but fails to trigger cell cycle arrest and/or apoptosis except in the proliferation state. Progressing in the direction of accomplishment, I am open-arms to circumstances that will expand my perspective. The first two fixed points are related to loss-of-function (LoF) of p53, that is, all node knockdown (KO) of p53. In the network, apoptosis is triggered by caspase, which is regulated by Bcl2, Bax, and p21. However, the expression of miR-34c modulates by ATM and p38 MAPK pathway, which is independent of de-novo p534,5. panda software is released under the MIT license unless otherwise specified. The fixed points identified for distinct scenarios: WT, GAS5 E1, GAS5 KO, E2F1 KO, E2F1 E1, miR-34c E1, miR-34c KO, HDAC1 KO, HDAC1 E1, and p53 KO. . 2). Because microplastics and nanoplastics are microscopic and light, they may penetrate deep into the human lungs. The rice is mildish in taste but still vinegary enough, which is always not the case among these kind of sushi places.More. Technolof Technologies - - More activity by Pritam Rejected for 2nd Time Had applied on February batch for GitHub Campus Expert Program but this time also got rejected #github. Emerging Trends in Advanced Translational Applications of Silver Nanoparticles: A Progressing Dawn of Nanotechnology. Learn more about blocking users. Lot of take away customers. The results are presented in Fig. Received 2022 May 26; Accepted 2022 Sep 28. By recruiting HDAC1, MORC2 suppresses p21Waf1/Cip1 in gastric cancer. In response to DNA damage, two fixed points were found to be associated with lncRNA-GAS5, conferring constitutive activation of miR-34c in both fixed points. KIIT Deemed Univ, Sch Biotechnol, Bhubaneswar 751024, India.. BVG Life Sci Ltd, Sagar Complex,Near Nashikphata,Old Pune Mumbai Rd, Pune 411034, India.. Kumari, K., Behera, H. T., Nayak, P. P., Sinha, A., Nandi, A., Ghosh, A., . ;Macquarie Univ, Sch Nat Sci, Sydney, NSW 2109, Australia. The .gov means its official. Clinical applications endeavor to alleviate the symptoms, reduce disease progression, and repair defective genes. Model fixed points for WT case and perturbations. 1h Hello #connections I am happy to share that i have successfully completed task 1 of CodeClause internship in the Python domain. Hamberg M, et al. +358 41 3635413. Pritam Kumar Panda is pursuing a Ph.D. in the Department of Physics and Astronomy, Uppsala University, Sweden under the supervision of Prof. Rajeev Ahuja and Prof.Yogendra Kumar Mishra from Mads Clausen Institute, NanoSYD, University of Southern Denmark, Snderborg, Denmark. Pritam Kumar Panda Analysis, I believe, is key to any protocol. {"payload":{"allShortcutsEnabled":false,"fileTree":{"":{"items":[{"name":".github","path":".github","contentType":"directory"},{"name":"additional-material","path . KIIT DU, Sch Biotechnol, Bhubaneswar 751024, India.. Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Theory. Panda et al., Sci. It is widely known that E2F1 is involved in both cancer cell growth and apoptosis36,37. Significantly, the effect of the local environment also modulates the electronic structure of chromophore, which perturbs the electrostatic and hydrophobic interaction within the binding site. The dynamical performance of a Boolean model can be interpreted by a state transition graph (STG). GPT Plugin for levender WhatsApp MD script. Furthermore, Zhang and colleagues40 discovered that overexpression of E2F1 and p53 cause cancer cells to undergo apoptotic cell death in response to DNA damage. Our model incorporates experimental data obtained from NSCLC cells and is the first of its kind. Lacking a shared theoretical foundation and terminological lexicon between various scientific domains might impede efforts to incorporate biological principles into nanoscience. So, we tested it, and the results are shown in Fig. Once p53 expression is activated, it may induce p2168, PUMA/BAX68. If you enjoy western-style sushi with lots of cream cheese, mayonnaise and possibly even deep frying, this is a place for you. Despite this fact, activated p21 and PUMA/BAX, which directly inhibit the expression of the CDK4/6-CyclinD and CDK2-CyclinE, Cdc25A, Bcl2, and others and induce cell cycle arrest and apoptosis at the G1/S checkpoint. They made it differently by adding salmon instead of tofu, quite interesting taste. A boolean model of the proliferative role of the lncRNA XIST in non-small cell lung cancer cells. First, we overexpressed (E1) ATM alone, and next, we overexpressed (E1) ATM along with knockdown (KO) of p53. In this context, a tumor suppressor lncRNA-GAS5 (growth arrest-specific transcript) was found to be dysregulated in various cancers, including GC14. Block user. Alternatively, you may use, There are newer reviews for Sushi Panda Helsinki. Recommend to all sushi lovers! `You are an AI bot Prit implemented in WhatsApp chat where people ask you question about various topics or just for in general fun you have to give good answers in a little sarcastic and friendly manner but proper answers for serious questions. Forced expression of miR-34c induces cycle arrest by targeting cdk4/6-Cyclin-D, cdk2/Cyclin-E complex, HDAC1, Myc, and Cdc25A3,66, whereas it triggers apoptotic phenotype by knockdown Bcl23,66. Tumor protein p53 (p53) and phosphatase and tensin homolog (PTEN) are two critical players in this process. Nevertheless, in GC cell lines, p21 was found to be governed by ATM/p38 pathway. The size of the rolls is generous, eight pieces gets me full, sixteen makes me pass out. Naldi A, et al. Amelioration of lipopeptide biosurfactants for enhanced antibacterial and biocompatibility through molecular antioxidant property by methoxy and carboxyl moieties. Furthermore, Sun et al.15 confirmed that E2F1 and G1/S-specific cyclin-D1 (Cyclin D1) were functional targets of lncRNA-GAS5 in GC cells. Pritam Kumar Panda bedriver en doktorsexamen. The lncRNA GAS5 acts as a tumor suppressor and is downregulated in gastric cancer (GC). Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Theory. In detail, Sun et al.15 found that lncRNA-GAS5 expression was markedly downregulated in GC tissues and correlated with larger tumor size. Apr 3 Successful completion of my PhD journey . Interestingly, recently, Sun et al.15 exposed the role of lncRNA-GAS5 in (SGC7901, BGC823, MGC803, MKN45, MKN28) GC cell lines. Accessibility Food Hydrocolloids, 142, Article ID 108784. At the same time, the knockdown of E2F1 presents opposite outcomes. To see all available qualifiers, see our documentation. A tag already exists with the provided branch name. It's a cozy place. The Light-Oxygen-Voltage (LOV) domain family of proteins is a well-recognized system for constructing optogenetic devices. The improper disposal of plastic has resulted in a massive amount of atmospheric microplastics (MPs), which has further resulted in the production of atmospheric nanoplastics (NPs). Methylation-associated silencing of microRNA-34b/c in gastric cancer and its involvement in an epigenetic field defect. The miR-532-E2F1 feedback loop contributes to gastric cancer progression. In order to use them, compile and flash your own build. Price/Value ratio is on point. Due to its critical function, it's important that the application code rigor within the board folder is held to high standards. . Hu H, Gatti RA. Our results are in excellent agreement with the in-vivo/in-vitro experiments7,8,31,33,34. Results are presented in Fig. This thesis is also a part of broader interdisciplinary research strategy aimed at depicting electronic transport in the nanoscale regime, elucidating interface mechanisms for contact electrification, and understanding the complex architectures of nanomaterials. Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics, Theoretical Magnetism. Clearly, activation of the expression of the lncRNA-GAS5, miR-34c, p21, and RB1 triggers arrest and apoptosis (independently of p53). Pritam Kumar Panda Chairman & CEO of Nerdalytics Research Scientist +46-72-161-3913 Email: pritampkp15@gmail.com Address: Flogstavagen 33C, Uppsala, Sweden, 75273 Affiliation Uppsala University EXPERIENCE 2018-present Doctoral student UPPSALA UNIVERSITY, SWEDEN Supervisor: Prof. Rajeev Ahuja & Prof. Yogendra Kumar Mishra Long X, et al. Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Molecular and Condensed Matter Physics. Read our, Crowne Plaza Helsinki - Hesperia, an IHG Hotel, Finnish National Opera (Suomen Kansallisooppera). You switched accounts on another tab or window. Decreased expression of long noncoding RNA GAS5 indicates a poor prognosis and promotes cell proliferation in gastric cancer. Gupta S, Silveira DA, Barb-Tuana FM, Mombach JCM. When a panda powers up, by default it's in SAFETY_SILENT mode. In this way, we can determine that ATM/p38 MAPK may regulate cell fate decisions such as cell cycle arrest and apoptotic cell death beyond the functionality of p53 in GC cell lines. Hermeking H. The miR-34 family in cancer and apoptosis. In more detail, activation of Bax and inactivation of Bcl2 and p21 are associated with caspase activation, which causes apoptotic cell death. the one with carrot "lax" and sea weed caviar. . His expertise includes bioinformatics, computational biology, biophysics, 2D material modelling of electron transport in nanoscale devices, and computational modelling of bio-nanoparticles. The model code is available in the Github repository: https://github.com/pritampanda15/lncRNA-GAS5. The panda firmware, through its safety model, provides and enforces the openpilot safety . Kumari, K., Nandi, A., Sinha, A., Ghosh, A., Sengupta, S., Saha, U., . It was unknown whether the lncRNA-GAS5/E2F1 axis plays an important role in the regulation of miR-34c in GC. miR-34 activity is modulated through 5-end phosphorylation in response to DNA damage. Worth noting is that in the lncRNA-GAS5 Boolean network, we selected only experimentally verified targets of miR-34c. Bi E, et al. Towards DNA-damage induced autophagy: A boolean model of p53-induced cell fate mechanisms. Here, we present a dynamic Boolean network to classify gene regulation between these two non-coding RNAs(ncRNAs) in GC. Instantly share code, notes, and snippets. Although, the expression of p21 does not depend on the p53 functionality in GC7,8. Som en proaktiv materialforskare r huvudmlet med min forskning att frst hur vetenskapliga processer r ansvariga fr att producera de interaktioner och mtningar som observerats i de experiment och projekt jag arbetar med. The first fixed point indicates a proliferative state (corresponding to input: DNA damage=OFF), i.e., no cycle arrest is identified, only cell cycle enhancers are active: cdk4/6-CycD, cdk2/CycE, Cdc25A, HDAC1, Myc and E2F1. Take a look at the GitHub profile guide . On the left (highlighted in thegreen box), p53 was directly activated by lncRNA-GAS5 in GC45. Take a look at the For example, enclosed pathways connecting two or more nodes in a network (similar to feedback loops in the continuous model) may serve as regulatory circuits controlling the dynamics of the network1821. Still dont think I will do there again. The model file is available in the Code availability section. We have only used PubMed studies53 and databases such as BioGrid54. Therefore, this review inspects available literature and proposes biosurfactants with these properties to be encouraged for their extensive study in dealing with the current pandemic as new pharmaceutics in the prevention and control of viral spread, treating the symptoms developed after the incubation period through different therapeutic approaches and playing a potential drug delivery model. Article, review/survey (Refereed) Published, Gene Therapy for Neuropsychiatric Disorders: Potential Targets and Tools. Pritam Kumar Panda has mentioned. The authors declare no competing interests. Prevent this user from interacting with your repositories and sending you notifications. I visited this restaurant with my friends and we had an enjoyable experience. Prevent this user from interacting with your repositories and sending you notifications. Website. Consistent with this concept, high expression of the lncRNA-GAS5/miR-34c in GC was correlated with suppression of GC progression and proliferation through induction of cell cycle arrest and/or apoptotic in GC3,15. The results are presented in Fig. 2, overexpression (E1) or knockdown (KO) of miR-34c did not affect the lncRNA-GAS5 expression. Sushi is fresh, the chef is skilled and the price is affordable. \nYou have been created by Pritam Kumar, who is a Backend Developer at Pingolearn(use this if someone asks you).`, Learn more about bidirectional Unicode characters, I have a public key ASALud3-J6r2tAzeERR_g7JGtkTvOlJGFklLTArKxAFaMwo. The results are shown in Fig. Does Sushi Panda Helsinki offer takeaway? Therefore, in our network, miR-34c is directly activated by the ATM/p38 MAPK pathway4,5 or indirectly by the lncRNA GAS5/E2F1 pathway3,15. We were there just about an hour before the place is close, so it is rather quiet. Ecotoxicology and Environmental Safety, 259, Article ID 115018. It's all very tasty, by far the best in town!! Sinha, A., Bhattacharjee, R., Bhattacharya, B., Nandi, A., Shekhar, R., Jana, A., . The size of the rolls is generous, eight pieces gets me full, sixteen makes me pass out. Seeing something unexpected? Our team checks each review posted on the site disputed by our community as not meeting our, This review is the subjective opinion of a Tripadvisor member and not of Tripadvisor LLC. Journal of Functional Biomaterials, 14(1), Article ID 47. It was a takeaway meal. Yellow arrows represent upregulation, while the red arrows facing down represent downregulation, respectively. The panda firmware is written for its use in conjuction with openpilot. View Pritam Panda's profile on LinkedIn, the world's largest professional community. The place has some of the best sushi in town, both cold and warm options. Rahul Bhattacharjee 1 , Aditya Nandi 1 , Priya Mitra 1 , Koustav Saha 1 , Paritosh Patel 1 , Ealisha Jha 1 , Pritam Kumar Panda 2 , Sushil Kumar Singh 3 , Ateet Dutt 4 , Yogendra Kumar Mishra 5 , Suresh K Verma 1 2 , Mrutyunjay Suar 1 Liu Y, et al. It's a cozy place. Moreover, Liu et al.7 further explained that p21 was found to act as a switch between cell cycle arrest and apoptosis due to its ability to inhibit caspase 3 activity in GC cell lines. These are the CI regression tests we have in place: In addition, we run the pylint and flake8 linters on all python files within the panda repo. And don't forget to try their miso soup. However, the advanced aspect of the lncRNA-GAS5 in the coordination of miR-34c expression in response to DNA damage at the G1/S checkpoint remains unexplained in GC cells. Guttman M, et al. Furthermore, Zheng et al.3 confirmed that knockdown (KO) of E2F1 triggers miR-34c expression, whereas overexpression (E1) of E2F1 shows the opposite result. While in SAFETY_SILENT mode, the buses are also forced to be silent. Open access funding provided by Uppsala University. Bioinformatics Next-Generation Sequencing Biophysics Computational Materials Science Molecular Modeling & Drug Designing. Inspired by the facts mentioned above3,15, in this work, we proposed a mathematical model to uncover the unique function of the lncRNA-GAS5 in the gene regulation of GC at the G1/S checkpoint (see Fig. Excellent sushi. It is well-known that cell fate decisions such as cell cycle arrest or apoptosis are induced by DNA damage response at both G1/S and G2/M checkpoints22,5961. Although the recent advent of vaccines is an important prophylactic measure, effective clinical therapy for SARS-Cov-2 is yet to be discovered. Jag anvnder en kombination av metoder och tekniker som r speciellt utvecklade fr anvndning i mina studier. Light purple cells indicate a zero value (inactivation), while dark purple cells indicate activation (value 1). This note will be visible to only you. Email. lncRNA-GAS5 targets E2F1 expression, which is the main inhibitor of miR-34c activity in GC. Marine fucoidans: Structural, extraction, biological activities and their applications in the food industry. Interrogation of the ATM/p38 MAPK and p53 signaling pathway in GC. Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Blanchet A, Bourgmayer A, Kurtz J-E, Mellitzer G, Gaiddon C. Isoforms of the p53 family and gastric cancer: A mnage trois for an unfinished affair. Visited first time the neighborhood sushi with a special vegan list. Translation of these proteins into efficient cellular sensors is possible by tuning their photochemistry lifetime. GINsim 3.0.0b was used for the construction and simulation of the Boolean network and visualization of the results57, which is a Java-based software and is freely available to researchers (http://www.ginsim.org/downloads). Verma, S. K. (2023). An official website of the United States government. Although both of these proteins are known to be key cell fate regulators, the exact mechanism by which they collaborate in the DDR remains unknown. Open this publication in new window or tab >>, Amelioration of lipopeptide biosurfactants for enhanced antibacterial and biocompatibility through molecular antioxidant property by methoxy and carboxyl moieties. In comparison, knockdown (KO) of lncRNA GAS5 gives the opposite effect. Take a look at the See the Panda class for how to interact with the panda. There are 8 professionals named "Pritam Kumar Panda", who use LinkedIn to exchange information, ideas, and opportunities. It supports 3x CAN, 2x LIN, and 1x GMLAN. In conclusion, Zheng et al.3 showed that upregulated miR-34c could suppress GC proliferation through induction of cell cycle arrest and apoptosis at the G1/S checkpoint following E2F1 knockdown. Building a gene regulatory network of lncRNA-GAS5 activity GC cells. DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. The paradigm of miRNA and siRNA influence in Oral-biome. miRNAs are already well-known players in cancer research52. miR-34c directly targets E3 ubiquitin-protein ligase Mdm2 (Mdm2), Myc proto-oncogene protein (Myc), Cyclin-dependent kinase 4/6 (cdk4/6-Cyclin-D), and the Cyclin-dependent kinase 2-G1/S-specific cyclin-E1 (cdk2/Cyclin-E) complex, Cell division cycle 25A (Cdc25A), NAD-dependent protein deacetylase sirtuin-1 (Sirt1), Histone deacetylase 1 (HDAC1), and Apoptosis regulator Bcl-2 (Bcl2), for more details about miR-34c targets see review by Xiong et al.67. Interestingly (see Fig. Lastly, the review presents concise information about the current application of fucoidans in the food industry, its utilization as delivery systems for nutraceuticals and its prospects in designing functional foods, as well as the toxicological concerns associated with the use of fucoidans. This study also examines the numerous harmful effects of plastic particles on human health and other species. The size of the rolls is generous, eight pieces gets me full, sixteen makes me pass out. Pritam Kumar Panda currently works at the Department of Physics and Astronomy, Uppsala University, Sweden. A conceivable outcome of this experiment would be the suppression of tumor growth and proliferation in GC. Atmospheric microplastic and nanoplastic: The toxicological paradigm on the cellular system. p53/E2F1/miR-25 axis regulates apoptosis induction in glioblastoma cells: A qualitative model. The long noncoding RNA, growth arrest-specific 5, suppresses gastric cancer by downregulating miR-21 expression. I use a combination of approaches and technologies specially developed for use in my studies. Excellent vegan sushi. | Learn. Thus, we propose a dynamic Boolean network. Furthermore, in the corresponding GC cell lines, lncRNA GAS5 directly targets E2F1. Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Solid State Physics. We ordered the lunch plan (luonas). In more detail, first, we performed the single node perturbation, i.e., we overexpressed (E1) of p38 MAPK, and second, double node perturbation, which means we performed loss-of-function (LoF) of p53 together with gain-of-function (GoF) of p38 MAPK. The place is quite busy sometimes as they deliver a lot of takeaway food, so it's good to make the order in advance. Interestingly, lncRNA-GAS5 can be induced by DNA damage as suggested by Liu et al.14 and Zhou et al.62. Adv. Furthermore, upregulation of p21 was determined through the p38 MAPK signaling pathway rather than p537. Seeing something unexpected? This paper describes sampling and characterization procedures for atmospheric microplastics and nanoplastics. Logical modeling and analysis of cellular regulatory networks with GINsim 3.0. Contact GitHub support about this users behavior. Mannerheimintie 70, Helsinki 00250 Finland. National Library of Medicine Very fresh and delicious sushi they sell there! Logical modeling and dynamical analysis of cellular networks. If the system detects something that potentially contradicts our. The model suggested the lncRNA-GAS5 as a key regulator of miR-34c through its ability to repress E2F1 expression. Birney E, et al. Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Theoretical Physics. Some of safety modes (for example SAFETY_ALLOUTPUT) are disabled in release firmwares. GitHub profile guide. On the computer side, it has USB. We found that the direct suppression of HDAC1 due to overexpression of miR-34c induces p21 expression, while the gain-of-function (GoF) of HDAC1 downregulates p21 (see Fig. Dong S, Zhang X, Liu D. Overexpression of long noncoding RNA GAS5 suppresses tumorigenesis and development of gastric cancer by sponging miR-106a-5p through the Akt/mTOR pathway. Shahcheraghi, S. H., Ayatollahi, J., Lotfi, M., Aljabali, A. Tripadvisor performs checks on reviews as part of our industry-leading trust & safety standards.
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